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Work from the Brown and Goldstein lab provided insights into cholesterol homeost

by | Nov 23, 2022 | Medicine | 0 comments

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Work from the Brown and Goldstein lab provided insights into cholesterol homeostasis that were used to develop several of the LDL cholesterol-lowering therapies, including statins that remain in use today. However, in some patients, statins were not as effective as expected, suggestive of additional mechanisms regulating the LDL receptor. After reading CH. 13 and the provided articles, Investigate other LDL cholesterol-lowering therapies (other than PCSK-9 inhibitors), select 1, and compare and contrast the mechanisms of action between the class of drug you select and statins. Include side effects for both types of drugs and information on their efficacy.
RESOURCES:
https://cdn.bc-pf.org/resources/biology/Molecular_biology/Wilson-Molecular_Biology_of_The_Cell_The_Problem_Book_6th_Edition.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC427113/pdf/pnas00137-0094.pdf
2nd article linked as pdf attachment

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